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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDK3 All Species: 18.48
Human Site: T276 Identified Species: 25.42
UniProt: Q00526 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.19
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q00526 NP_001249.1 305 35046 T276 Y D P S Q R I T A K T A L A H
Chimpanzee Pan troglodytes XP_523720 325 36841 T296 Y D P S Q R I T A K T A L A H
Rhesus Macaque Macaca mulatta XP_001102596 305 34903 T276 Y D P S R R I T A K T A L A H
Dog Lupus familis XP_540442 303 34173 S274 Y D P S Q R I S A K A A L V H
Cat Felis silvestris
Mouse Mus musculus Q80YP0 303 33870 S275 Y D P S Q R I S A K T A L A H
Rat Rattus norvegicus Q63699 298 33869 H268 S L L S Q M L H Y D P N K R I
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P13863 303 34670 R275 L I Y D P A K R I S G K M A L
Frog Xenopus laevis P23437 297 33852 Q268 D L L A Q M L Q Y D S N K R I
Zebra Danio Brachydanio rerio NP_998571 298 34001 T268 D L L G Q M L T Y D P N K R I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P23572 297 34420 L268 I D L I Q K M L I Y D P V H R
Honey Bee Apis mellifera XP_393450 299 34033 P270 L K L L T Y D P N Q R I T A K
Nematode Worm Caenorhab. elegans P34556 332 38277 N302 Y D P S L R L N A K K A L V H
Sea Urchin Strong. purpuratus XP_790847 299 34142 C268 D L L K S M L C Y E P D K R I
Poplar Tree Populus trichocarpa XP_002306004 294 33768 D262 T L E K A G V D L L S K M L F
Maize Zea mays P23111 294 33816 D262 N L D P A G L D L L S K M L R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P24100 294 34012 D262 N L D P D G V D L L S K M L L
Baker's Yeast Sacchar. cerevisiae P00546 298 34043 D270 S L D P R G I D L L D K L L A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.5 96.7 88.5 N.A. 82.6 74.7 N.A. N.A. 63.6 73.7 73.7 N.A. 62.9 67.2 58.1 69.5
Protein Similarity: 100 93.5 98.3 92.7 N.A. 91.8 84.5 N.A. N.A. 78 84.5 83.2 N.A. 76.7 80.6 69.5 82.6
P-Site Identity: 100 100 93.3 80 N.A. 93.3 13.3 N.A. N.A. 6.6 6.6 13.3 N.A. 13.3 6.6 66.6 0
P-Site Similarity: 100 100 100 86.6 N.A. 100 20 N.A. N.A. 13.3 26.6 20 N.A. 33.3 13.3 73.3 13.3
Percent
Protein Identity: 65.2 64.2 N.A. 65.5 62.3 N.A.
Protein Similarity: 81.6 80.9 N.A. 81.3 77.7 N.A.
P-Site Identity: 0 0 N.A. 0 13.3 N.A.
P-Site Similarity: 20 20 N.A. 20 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 6 12 6 0 0 36 0 6 36 0 36 6 % A
% Cys: 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 % C
% Asp: 18 42 18 6 6 0 6 24 0 18 12 6 0 0 0 % D
% Glu: 0 0 6 0 0 0 0 0 0 6 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 % F
% Gly: 0 0 0 6 0 24 0 0 0 0 6 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 6 0 0 0 0 0 6 36 % H
% Ile: 6 6 0 6 0 0 36 0 12 0 0 6 0 0 24 % I
% Lys: 0 6 0 12 0 6 6 0 0 36 6 30 24 0 6 % K
% Leu: 12 48 36 6 6 0 36 6 24 24 0 0 42 24 12 % L
% Met: 0 0 0 0 0 24 6 0 0 0 0 0 24 0 0 % M
% Asn: 12 0 0 0 0 0 0 6 6 0 0 18 0 0 0 % N
% Pro: 0 0 36 18 6 0 0 6 0 0 18 6 0 0 0 % P
% Gln: 0 0 0 0 48 0 0 6 0 6 0 0 0 0 0 % Q
% Arg: 0 0 0 0 12 36 0 6 0 0 6 0 0 24 12 % R
% Ser: 12 0 0 42 6 0 0 12 0 6 24 0 0 0 0 % S
% Thr: 6 0 0 0 6 0 0 24 0 0 24 0 6 0 0 % T
% Val: 0 0 0 0 0 0 12 0 0 0 0 0 6 12 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 36 0 6 0 0 6 0 0 24 6 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _